Our original Universal Support (20-5000) has been discontinued since complete dephosphorylation using ammonium hydroxide, AMA or anhydrous methylamine gas takes longer than most companies wish to allocate.A recent development has been the use of a support based on a molecule which is "conformationally preorganized" to accelerate the dephosphorylation reaction.1,2By using a rigid bicyclic molecule on the support, the rate of elimination is markedly faster than the original Universal Support.The structure of Glen UnySupport is shown below.The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligo synthesis.Glen UnySupport is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection.We are happy to offer Glen UnySupport in a variety of popular formats under license from Isis Pharmaceuticals.